Proteasome activator complex PA28 identified as an accessible target in prostate cancer by in vivo selection of human antibodies

Antibody cancer therapies rely on systemically accessible targets and suitable antibodies that exert a functional activity or deliver a payload to the tumor site. Here, we present proof-of-principle of in vivo selection of human antibodies in tumor-bearing mice that identified a tumor-specific antib...

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Hlavní autoři: Sánchez-Martín, David, Martínez-Torrecuadrada, Jorge, Teesalu, Tambet, Sugahara, Kazuki N., Alvarez-Cienfuegos, Ana, Ximénez-Embún, Pilar, Fernández-Periáñez, Rodrigo, Martín, M. Teresa, Molina-Privado, Irene, Ruppen-Cañás, Isabel, Blanco-Toribio, Ana, Cañamero, Marta, Cuesta, Ángel M., Compte, Marta, Kremer, Leonor, Bellas, Carmen, Alonso-Camino, Vanesa, Guijarro-Muñoz, Irene, Sanz, Laura, Ruoslahti, Erkki, Alvarez-Vallina, Luis
Médium: Artigo
Jazyk:Inglês
Vydáno: National Academy of Sciences 2013
Témata:
Biological Sciences
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3752212/
https://ncbi.nlm.nih.gov/pubmed/23918357
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1300013110
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