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MC1R and cAMP signaling inhibit cdc25B activity and delay cell cycle progression in melanoma cells
The melanocortin 1 receptor (MC1R) mediates the tanning response through induction of cAMP and downstream pigmentary enzymes. Diminished function alleles of MC1R are associated with decreased tanning and increased melanoma risk, which has been attributed to increased rates of mutation. We have found...
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| Hauptverfasser: | , , |
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| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
National Academy of Sciences
2013
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3752210/ https://ncbi.nlm.nih.gov/pubmed/23908401 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1201917110 |
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