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MC1R and cAMP signaling inhibit cdc25B activity and delay cell cycle progression in melanoma cells

The melanocortin 1 receptor (MC1R) mediates the tanning response through induction of cAMP and downstream pigmentary enzymes. Diminished function alleles of MC1R are associated with decreased tanning and increased melanoma risk, which has been attributed to increased rates of mutation. We have found...

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Detalhes bibliográficos
Main Authors: Lyons, Jesse, Bastian, Boris C., McCormick, Frank
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2013
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3752210/
https://ncbi.nlm.nih.gov/pubmed/23908401
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1201917110
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