Apolipoprotein E fragments present in Alzheimer's disease brains induce neurofibrillary tangle-like intracellular inclusions in neurons

Human apolipoprotein (apo) E4, a major risk factor for Alzheimer's disease (AD), occurs in amyloid plaques and neurofibrillary tangles (NFTs) in AD brains; however, its role in the pathogenesis of these lesions is unclear. Here we demonstrate that carboxyl-terminal-truncated forms of apoE, whic...

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Bibliographic Details
Main Authors: Huang, Yadong, Liu, Xiao Qin, Wyss-Coray, Tony, Brecht, Walter J., Sanan, David A., Mahley, Robert W.
Format: Artigo
Language:Inglês
Published: The National Academy of Sciences 2001
Subjects:
Biological Sciences
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC37522/
https://ncbi.nlm.nih.gov/pubmed/11447277
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.151254698
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