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Potent cardioprotection from ischemia-reperfusion injury by a 2-domain fusion protein comprising Annexin V and Kunitz protease inhibitor
BACKGROUND: Considerable evidence suggests that coagulation proteases (TF/FVIIa/FXa/thrombin) and their target protease activated receptors (PAR-1/PAR-2) play important roles in myocardial ischemia-reperfusion (I-R) injury. We hypothesized that localized inhibition of TF/FVIIa on the membrane surfac...
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| Main Authors: | , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2013
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3752160/ https://ncbi.nlm.nih.gov/pubmed/23746209 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/jth.12314 |
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