Neuronal Hypoxia Induces Hsp40-Mediated Nuclear Import of Type 3 Deiodinase As an Adaptive Mechanism to Reduce Cellular Metabolism

In neurons, the type 3 deiodinase (D3) inactivates thyroid hormone and reduces oxygen consumption, thus creating a state of cell-specific hypothyroidism. Here we show that hypoxia leads to nuclear import of D3 in neurons, without which thyroid hormone signaling and metabolism cannot be reduced. Afte...

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Bibliographic Details
Main Authors: Jo, Sungro, Kalló, Imre, Bardóczi, Zsuzsanna, Arrojo e Drigo, Rafael, Zeöld, Anikó, Liposits, Zsolt, Oliva, Anthony, Lemmon, Vance P., Bixby, John L., Gereben, Balázs, Bianco, Antonio C.
Format: Artigo
Language:Inglês
Published: Society for Neuroscience 2012
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3752066/
https://ncbi.nlm.nih.gov/pubmed/22723689
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.6514-11.2012
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