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Enhanced antitumor efficacy of a herpes simplex virus mutant isolated by genetic selection in cancer cells
Replication-competent, attenuated herpes simplex virus-1 (HSV-1) derivatives that contain engineered mutations into the viral γ34.5 virulence gene have been used as oncolytic agents. However, as attenuated mutants often grow poorly, they may not completely destroy some tumors and surviving cancer ce...
Tallennettuna:
| Päätekijät: | , , , , |
|---|---|
| Aineistotyyppi: | Artigo |
| Kieli: | Inglês |
| Julkaistu: |
The National Academy of Sciences
2001
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| Aiheet: | |
| Linkit: | https://ncbi.nlm.nih.gov/pmc/articles/PMC37516/ https://ncbi.nlm.nih.gov/pubmed/11438715 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.161011798 |
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