Cysteine-rich domain of scavenger receptor AI modulates the efficacy of surface targeting and mediates oligomeric Aβ internalization

BACKGROUND: Insufficient clearance of soluble oligomeric amyloid-β peptide (oAβ) in the central nervous system leads to the synaptic and memory deficits in Alzheimer's disease (AD). Previously we have identified scavenger receptor class A (SR-A) of microglia mediates oligomeric amyloid-β peptid...

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Detalhes bibliográficos
Main Authors: Huang, Fong-Lee, Shiao, Young-Ji, Hou, Sheue-Jane, Yang, Cheng-Ning, Chen, Yi-Jen, Lin, Chao-Hsiung, Shie, Feng-Shiun, Tsay, Huey-Jen
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2013
Assuntos:
Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3750411/
https://ncbi.nlm.nih.gov/pubmed/23915271
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1423-0127-20-54
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