ERK-associated changes in E2F4 phosphorylation, localization and transcriptional activity during mitogenic stimulation in human intestinal epithelial crypt cells

BACKGROUND: The transcription factor E2F4 controls proliferation of normal and cancerous intestinal epithelial cells. E2F4 localization in normal human intestinal epithelial cells (HIEC) is cell cycle-dependent, being cytoplasmic in quiescent differentiated cells but nuclear in proliferative cells....

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Bibliographic Details
Main Authors: Paquin, Marie-Christine, Cagnol, Sébastien, Carrier, Julie C, Leblanc, Caroline, Rivard, Nathalie
Format: Artigo
Language:Inglês
Published: BioMed Central 2013
Subjects:
Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3750237/
https://ncbi.nlm.nih.gov/pubmed/23919615
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1471-2121-14-33
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