The STRA6 Receptor Is Essential for Retinol-binding Protein-induced Insulin Resistance but Not for Maintaining Vitamin A Homeostasis in Tissues Other Than the Eye

The plasma membrane protein STRA6 is thought to mediate uptake of retinol from its blood carrier retinol-binding protein (RBP) into cells and to function as a surface receptor that, upon binding of holo-RBP, activates a JAK/STAT cascade. It was suggested that STRA6 signaling underlies insulin resist...

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Main Authors: Berry, Daniel C., Jacobs, Hugues, Marwarha, Gurdeep, Gely-Pernot, Aurore, O'Byrne, Sheila M., DeSantis, David, Klopfenstein, Muriel, Feret, Betty, Dennefeld, Christine, Blaner, William S., Croniger, Colleen M., Mark, Manuel, Noy, Noa, Ghyselinck, Norbert B.
Formáid: Artigo
Teanga:Inglês
Foilsithe: American Society for Biochemistry and Molecular Biology 2013
Ábhair:
Metabolism
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC3750151/
https://ncbi.nlm.nih.gov/pubmed/23839944
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M113.484014
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