PROTEASOME INHIBITION BY BORTEZOMIB INCREASES IL-8 EXPRESSION IN ANDROGEN-INDEPENDENT PROSTATE CANCER CELLS: THE ROLE OF IKKα()

Expression of the pro-inflammatory and pro-angiogenic chemokine interleukin-8 (IL-8), which is regulated at the transcriptional level by NFκB, is constitutively increased in the androgen independent metastatic prostate cancer and correlates with poor prognosis. Inhibition of NFκB-dependent transcrip...

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Détails bibliographiques
Auteurs principaux: Manna, Subrata, Singha, Bipradeb, Phyo, Sai Aung, Gatla, Himavanth Reddy, Chang, Tzu-Pei, Sanacora, Shannon, Ramaswami, Sitharam, Vancurova, Ivana
Format: Artigo
Langue:Inglês
Publié: 2013
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Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC3750091/
https://ncbi.nlm.nih.gov/pubmed/23894194
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4049/jimmunol.1300895
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