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The Architecture of a Prototypical Bacterial Signaling Circuit Enables a Single Point Mutation to Confer Novel Network Properties

Even a single mutation can cause a marked change in a protein's properties. When the mutant protein functions within a network, complex phenotypes may emerge that are not intrinsic properties of the protein itself. Network architectures that enable such dramatic changes in function from a few m...

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Hlavní autoři: Ram, Sri, Goulian, Mark
Médium: Artigo
Jazyk:Inglês
Vydáno: Public Library of Science 2013
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3750022/
https://ncbi.nlm.nih.gov/pubmed/23990799
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pgen.1003706
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