An antisense approach to phenotype-based gene cloning in Tetrahymena

We report a pioneering approach using Tetrahymena thermophila that permits rapid identification of genes based on their null or hypomorphic phenotypes. This technique involves cell transformation with a library of plasmids that encode 26S ribosomal subunits containing short insertions. The insertion...

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Bibliografiske detaljer

Udgivet i:	Proc Natl Acad Sci U S A
Principais autores:	Chilcoat, N. Doane, Elde, Nels C., Turkewitz, Aaron P.
Format:	Artigo
Sprog:	Inglês
Udgivet:	National Academy of Sciences 2001
Fag:	Biological Sciences
Online adgang:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC37500/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/11438705/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.151243498
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