Developmental and species-divergent globin switching are driven by BCL11A

The contribution of changes in cis-regulatory elements or trans-acting factors to interspecies differences in gene expression is not well understood. The mammalian β-globin loci have served as a paradigm for gene regulation during development. Transgenic mice harboring the human β-globin locus, cons...

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Hauptverfasser: Sankaran, Vijay G., Xu, Jian, Ragoczy, Tobias, Ippolito, Gregory C., Walkley, Carl R., Maika, Shanna D., Fujiwara, Yuko, Ito, Masafumi, Groudine, Mark, Bender, M.A., Tucker, Philip W., Orkin, Stuart H.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2009
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3749913/
https://ncbi.nlm.nih.gov/pubmed/19657335
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nature08243
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