Somatic mosaicism in Wiskott–Aldrich syndrome suggests in vivo reversion by a DNA slippage mechanism

Somatic mosaicism caused by in vivo reversion of inherited mutations has been described in several human genetic disorders. Back mutations resulting in restoration of wild-type sequences and second-site mutations leading to compensatory changes have been shown in mosaic individuals. In most cases, h...

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Detalles Bibliográficos

Publicado en:	Proc Natl Acad Sci U S A
Principais autores:	Wada, Taizo, Schurman, Shepherd H., Otsu, Makoto, Garabedian, Elizabeth K., Ochs, Hans D., Nelson, David L., Candotti, Fabio
Formato:	Artigo
Idioma:	Inglês
Publicado:	National Academy of Sciences 2001
Assuntos:	Biological Sciences
Acceso en liña:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC37498/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/11447283/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.151260498
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