Transient B-Cell Depletion Combined With Apoptotic Donor Splenocytes Induces Xeno-Specific T- and B-Cell Tolerance to Islet Xenografts

Peritransplant infusion of apoptotic donor splenocytes cross-linked with ethylene carbodiimide (ECDI-SPs) has been demonstrated to effectively induce allogeneic donor-specific tolerance. The objective of the current study is to determine the effectiveness and additional requirements for tolerance in...

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Detalhes bibliográficos
Main Authors: Wang, Shusen, Tasch, James, Kheradmand, Taba, Ulaszek, Jodie, Ely, Sora, Zhang, Xiaomin, Hering, Bernhard J., Miller, Stephen D., Luo, Xunrong
Formato: Artigo
Idioma:Inglês
Publicado em: American Diabetes Association 2013
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Original Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3749362/
https://ncbi.nlm.nih.gov/pubmed/23852699
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2337/db12-1678
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