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Proteotoxic stress induces a cell cycle arrest by stimulating Lon to degrade the replication initiator DnaA

The decision to initiate DNA replication is a critical step in the cell cycle of all organisms. Cells often delay replication in the face of stressful conditions, but the underlying mechanisms remain incompletely defined. Here, we demonstrate in Caulobacter crescentus that proteotoxic stress induces...

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Hlavní autoři: Jonas, Kristina, Liu, Jing, Chien, Peter, Laub, Michael T.
Médium: Artigo
Jazyk:Inglês
Vydáno: 2013
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3749246/
https://ncbi.nlm.nih.gov/pubmed/23911325
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cell.2013.06.034
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