Platelets Promote Tumor Growth and Metastasis via Direct Interaction between Aggrus/Podoplanin and CLEC-2

The platelet aggregation-inducing factor Aggrus, also known as podoplanin, is frequently upregulated in several types of tumors and enhances hematogenous metastasis by interacting with and activating the platelet receptor CLEC-2. Thus, Aggrus–CLEC-2 binding could be a therapeutic molecular mechanism...

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Bibliografiske detaljer
Main Authors: Takagi, Satoshi, Sato, Shigeo, Oh-hara, Tomoko, Takami, Miho, Koike, Sumie, Mishima, Yuji, Hatake, Kiyohiko, Fujita, Naoya
Format: Artigo
Sprog:Inglês
Udgivet: Public Library of Science 2013
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3749157/
https://ncbi.nlm.nih.gov/pubmed/23991201
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0073609
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