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New Binding Site Conformations of the Dengue Virus NS3 Protease Accessed by Molecular Dynamics Simulation

Dengue fever is caused by four distinct serotypes of the dengue virus (DENV1-4), and is estimated to affect over 500 million people every year. Presently, there are no vaccines or antiviral treatments for this disease. Among the possible targets to fight dengue fever is the viral NS3 protease (NS3(P...

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Detalhes bibliográficos
Main Authors: de Almeida, Hugo, Bastos, Izabela M. D., Ribeiro, Bergmann M., Maigret, Bernard, Santana, Jaime M.
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2013
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3749139/
https://ncbi.nlm.nih.gov/pubmed/23991109
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0072402
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