Unique Transcriptional Profile of Sustained Ligand-Activated Preconditioning in Pre- and Post-Ischemic Myocardium

BACKGROUND: Opioidergic SLP (sustained ligand-activated preconditioning) induced by 3–5 days of opioid receptor (OR) agonism induces persistent protection against ischemia-reperfusion (I-R) injury in young and aged hearts, and is mechanistically distinct from conventional preconditioning responses....

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Autori principali: Ashton, Kevin J., Tupicoff, Amanda, Williams-Pritchard, Grant, Kiessling, Can J., See Hoe, Louise E., Headrick, John P., Peart, Jason N.
Natura: Artigo
Lingua:Inglês
Pubblicazione: Public Library of Science 2013
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Research Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3749099/
https://ncbi.nlm.nih.gov/pubmed/23991079
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0072278
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