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In silico identification of EGFR-T790M inhibitors with novel scaffolds: start with extraction of common features
BACKGROUND: Epidermal growth factor receptor (EGFR) is an attractive therapeutic target for a number of human tumors including non-small cell lung cancer (NSCLC). Most patients with NSCLC and somatic mutations have shown a dramatic initial clinical response to reversible EGFR inhibitors. The clinica...
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| Main Authors: | , , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Dove Medical Press
2013
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3748928/ https://ncbi.nlm.nih.gov/pubmed/23990708 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2147/DDDT.S41305 |
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