Identification of 2-Piperidone as a Biomarker of CYP2E1 Activity Through Metabolomic Phenotyping

Cytochrome P450 2E1 (CYP2E1) is a key enzyme in the metabolic activation of many low molecular weight toxicants and also an important contributor to oxidative stress. A noninvasive method to monitor CYP2E1 activity in vivo would be of great value for studying the role of CYP2E1 in chemical-induced t...

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Detalhes bibliográficos
Main Authors: Cheng, Jie, Chen, Chi, Kristopher, Krausz W., Manna, Soumen K., Scerba, Mike, Friedman, Fred K., Luecke, Hans, Idle, Jeffrey R., Gonzalez, Frank J.
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2013
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3748767/
https://ncbi.nlm.nih.gov/pubmed/23811823
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/toxsci/kft143
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