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Cortical region-specific engraftment of embryonic stem cell-derived neural progenitor cells restores axonal sprouting to a subcortical target and achieves motor functional recovery in a mouse model of neonatal hypoxic-ischemic brain injury

Hypoxic-ischemic encephalopathy (HIE) at birth could cause cerebral palsy (CP), mental retardation, and epilepsy, which last throughout the individual's lifetime. However, few restorative treatments for ischemic tissue are currently available. Cell replacement therapy offers the potential to re...

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Autors principals: Shinoyama, Mizuya, Ideguchi, Makoto, Kida, Hiroyuki, Kajiwara, Koji, Kagawa, Yoshiteru, Maeda, Yoshihiko, Nomura, Sadahiro, Suzuki, Michiyasu
Format: Artigo
Idioma:Inglês
Publicat: Frontiers Media S.A. 2013
Matèries:
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3748369/
https://ncbi.nlm.nih.gov/pubmed/23970853
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fncel.2013.00128
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