A novel trigger for cholesterol-dependent smooth muscle contraction mediated by the sphingosylphosphorylcholine-Rho-kinase pathway in the rat basilar artery: a mechanistic role for lipid rafts

Hyperlipidemia is a risk factor for abnormal cerebrovascular events. Rafts are cholesterol-enriched membrane microdomains that influence signal transduction. We previously showed that Rho-kinase-mediated Ca(2+) sensitization of vascular smooth muscle (VSM) induced by sphingosylphosphorylcholine (SPC...

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Vydáno v:J Cereb Blood Flow Metab
Hlavní autoři: Shirao, Satoshi, Yoneda, Hiroshi, Shinoyama, Mizuya, Sugimoto, Kazutaka, Koizumi, Hiroyasu, Ishihara, Hideyuki, Oka, Fumiaki, Sadahiro, Hirokazu, Nomura, Sadahiro, Fujii, Masami, Tamechika, Masakatsu, Kagawa, Yoshiteru, Owada, Yuji, Suzuki, Michiyasu
Médium: Artigo
Jazyk:Inglês
Vydáno: Nature Publishing Group 2015
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Original Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4420858/
https://ncbi.nlm.nih.gov/pubmed/25605290
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/jcbfm.2014.260
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