CDK8-Mediated STAT1-S727 Phosphorylation Restrains NK Cell Cytotoxicity and Tumor Surveillance

The transcription factor STAT1 is important in natural killer (NK) cells, which provide immediate defense against tumor and virally infected cells. We show that mutation of a single phosphorylation site (Stat1-S727A) enhances NK cell cytotoxicity against a range of tumor cells, accompanied by increa...

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Gorde:
Xehetasun bibliografikoak
Egile Nagusiak: Putz, Eva Maria, Gotthardt, Dagmar, Hoermann, Gregor, Csiszar, Agnes, Wirth, Silvia, Berger, Angelika, Straka, Elisabeth, Rigler, Doris, Wallner, Barbara, Jamieson, Amanda M., Pickl, Winfried F., Zebedin-Brandl, Eva Maria, Müller, Mathias, Decker, Thomas, Sexl, Veronika
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: Cell Press 2013
Gaiak:
Report
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC3748339/
https://ncbi.nlm.nih.gov/pubmed/23933255
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2013.07.012
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