CDK8-Mediated STAT1-S727 Phosphorylation Restrains NK Cell Cytotoxicity and Tumor Surveillance

The transcription factor STAT1 is important in natural killer (NK) cells, which provide immediate defense against tumor and virally infected cells. We show that mutation of a single phosphorylation site (Stat1-S727A) enhances NK cell cytotoxicity against a range of tumor cells, accompanied by increa...

ver descrição completa

Na minha lista:
Detalhes bibliográficos
Main Authors: Putz, Eva Maria, Gotthardt, Dagmar, Hoermann, Gregor, Csiszar, Agnes, Wirth, Silvia, Berger, Angelika, Straka, Elisabeth, Rigler, Doris, Wallner, Barbara, Jamieson, Amanda M., Pickl, Winfried F., Zebedin-Brandl, Eva Maria, Müller, Mathias, Decker, Thomas, Sexl, Veronika
Formato: Artigo
Idioma:Inglês
Publicado em: Cell Press 2013
Assuntos:
Report
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3748339/
https://ncbi.nlm.nih.gov/pubmed/23933255
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2013.07.012
Tags: Adicionar Tag
Sem tags, seja o primeiro a adicionar uma tag!

Registos relacionados