Elimination of Von Hippel-Lindau Function Perturbs Pancreas Endocrine Homeostasis in Mice

Mutations in the human homolog of the Vhlh gene [encoding the von-Hippel Lindau (VHL) protein] lead to tumor development. In mice, depletion of Vhlh in pancreatic ß-cells causes perturbed glucose homeostasis, but the role of this gene in other pancreatic cells is poorly understood. To investigate th...

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Bibliographic Details
Main Authors: Puri, Sapna, García-Núñez, Alejandro, Hebrok, Matthias, Cano, David A.
Format: Artigo
Language:Inglês
Published: Public Library of Science 2013
Subjects:
Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3748057/
https://ncbi.nlm.nih.gov/pubmed/23977255
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0072213
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