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Induction of Leptin Resistance by Activation of cAMP-Epac Signaling

Leptin regulates energy balance and glucose homeostasis. Shortly after leptin was identified, it was established that obesity is commonly associated with leptin resistance, though the molecular mechanisms remain to be identified. To explore potential mechanisms of leptin resistance, we employed orga...

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Autores principales: Fukuda, Makoto, Williams, Kevin W., Gautron, Laurent, Elmquist, Joel K.
Formato: Artigo
Lenguaje:Inglês
Publicado: 2011
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Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC3747952/
https://ncbi.nlm.nih.gov/pubmed/21356522
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cmet.2011.01.016
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