Comparison of tocilizumab monotherapy versus methotrexate monotherapy in patients with moderate to severe rheumatoid arthritis: the AMBITION study

BACKGROUND: The anti-interleukin (IL) 6 receptor antibody tocilizumab inhibits signalling of IL6, a key cytokine in rheumatoid arthritis (RA) pathogenesis. OBJECTIVE: To evaluate through the AMBITION study the efficacy and safety of tocilizumab monotherapy versus methotrexate in patients with active...

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Main Authors: Jones, G, Sebba, A, Gu, J, Lowenstein, M B, Calvo, A, Gomez-Reino, J J, Siri, D A, Tomšič, M, Alecock, E, Woodworth, T, Genovese, M C
Formato: Artigo
Idioma:Inglês
Publicado: BMJ Group 2010
Assuntos:
Clinical and Epidemiological Research
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC3747519/
https://ncbi.nlm.nih.gov/pubmed/19297346
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1136/ard.2008.105197
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