Effect of Folic Acid and Vitamin B(12) on Pemetrexed Antifolate Chemotherapy in Nutrient Lung Cancer Cells

Pemetrexed (MTA) is a multitargeted antifolate drug approved for lung cancer therapy. Clinically, supplementation with high doses of folic acid (FA) and vitamin B(12) (VB12) lowers MTA cytotoxicities. An antagonistic effect of FA/VB12 on MTA efficacy has been proposed. However, patients who receive...

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Detalhes bibliográficos
Main Authors: Yang, Tsung-Ying, Chang, Gee-Chen, Hsu, Shih-Lan, Huang, Yi-Rou, Chiu, Ling-Yen, Sheu, Gwo-Tarng
Formato: Artigo
Idioma:Inglês
Publicado em: Hindawi Publishing Corporation 2013
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3747471/
https://ncbi.nlm.nih.gov/pubmed/23984356
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1155/2013/389046
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