An In-Depth Characterization of the Major Psoriasis Susceptibility Locus Identifies Candidate Susceptibility Alleles within an HLA-C Enhancer Element

Psoriasis is an immune-mediated skin disorder that is inherited as a complex genetic trait. Although genome-wide association scans (GWAS) have identified 36 disease susceptibility regions, more than 50% of the genetic variance can be attributed to a single Major Histocompatibility Complex (MHC) locu...

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Detalhes bibliográficos
Main Authors: Clop, Alex, Bertoni, Anna, Spain, Sarah L., Simpson, Michael A., Pullabhatla, Venu, Tonda, Raul, Hundhausen, Christian, Di Meglio, Paola, De Jong, Pieter, Hayday, Adrian C., Nestle, Frank O., Barker, Jonathan N., Bell, Robert J. A., Capon, Francesca, Trembath, Richard C.
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2013
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3747202/
https://ncbi.nlm.nih.gov/pubmed/23990973
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0071690
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