A mutant cholera toxin B subunit that binds GM1- ganglioside but lacks immunomodulatory or toxic activity

GM1-ganglioside receptor binding by the B subunit of cholera toxin (CtxB) is widely accepted to initiate toxin action by triggering uptake and delivery of the toxin A subunit into cells. More recently, GM1 binding by isolated CtxB, or the related B subunit of Escherichia coli heat-labile enterotoxin...

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Pubblicato in:	Proc Natl Acad Sci U S A
Autori principali:	Aman, A. T., Fraser, S., Merritt, E. A., Rodigherio, C., Kenny, M., Ahn, M., Hol, W. G. J., Williams, N. A., Lencer, W. I., Hirst, T. R.
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	National Academy of Sciences 2001
Soggetti:	Biological Sciences
Accesso online:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC37471/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/11447291/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.161273098
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