BRCA1 promotes the ubiquitination of PCNA and recruitment of translesion polymerases in response to replication blockade

Breast cancer gene 1 (BRCA1) deficient cells not only are hypersensitive to double-strand breaks but also are hypersensitive to UV irradiation and other agents that cause replication blockade; however, the molecular mechanisms behind these latter sensitivities are largely unknown. Here, we report th...

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Detalhes bibliográficos
Main Authors: Tian, Fen, Sharma, Shilpy, Zou, Jianqiu, Lin, Shiaw-Yih, Wang, Bin, Rezvani, Khosrow, Wang, Hongmin, Parvin, Jeffrey D., Ludwig, Thomas, Canman, Christine E., Zhang, Dong
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2013
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3746927/
https://ncbi.nlm.nih.gov/pubmed/23901102
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1306534110
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