Aurora B and Cdk1 mediate Wapl activation and release of acetylated cohesin from chromosomes by phosphorylating Sororin

Sister chromatid cohesion depends on Sororin, a protein that stabilizes acetylated cohesin complexes on DNA by antagonizing the cohesin release factor Wings-apart like protein (Wapl). Cohesion is essential for chromosome biorientation but has to be dissolved to enable sister chromatid separation. To...

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Main Authors: Nishiyama, Tomoko, Sykora, Martina M., Huis in ’t Veld, Pim J., Mechtler, Karl, Peters, Jan-Michael
Format: Artigo
Jezik:Inglês
Izdano: National Academy of Sciences 2013
Teme:
Biological Sciences
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3746921/
https://ncbi.nlm.nih.gov/pubmed/23901111
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1305020110
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