Prolonged exposure to GH impairs insulin signaling in the heart

Acromegaly is associated with cardiac hypertrophy, which is believed to be a direct consequence of chronically elevated GH and IGF1. Given that insulin is important for cardiac growth and function, and considering that GH excess induces hyperinsulinemia, insulin resistance, and cardiac alterations,...

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Main Authors: Miquet, J G, Giani, J F, Martinez, C S, Muñoz, M C, González, L, Sotelo, A I, Boparai, R K, Masternak, M M, Bartke, A, Dominici, F P, Turyn, D
Formato: Artigo
Idioma:Inglês
Publicado: 2011
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC3746341/
https://ncbi.nlm.nih.gov/pubmed/21727153
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1530/JME-11-0066
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