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Prolonged exposure to GH impairs insulin signaling in the heart
Acromegaly is associated with cardiac hypertrophy, which is believed to be a direct consequence of chronically elevated GH and IGF1. Given that insulin is important for cardiac growth and function, and considering that GH excess induces hyperinsulinemia, insulin resistance, and cardiac alterations,...
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| Main Authors: | , , , , , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2011
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3746341/ https://ncbi.nlm.nih.gov/pubmed/21727153 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1530/JME-11-0066 |
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