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Notching up MYC gives a LIC

King et al. (Cell, 2013) show that mutations in the ubiquitin ligase subcomponent FBXW7 increase MYC protein levels and expand the number of leukemia initiating cells (LIC) in Notch1-induced T-ALL. Genetic and pharmacological inhibition of Myc abolishes LIC activity with broader therapeutic implicat...

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Bibliografische gegevens
Hoofdauteurs: Levens, David, Aplan, Peter D.
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: 2013
Onderwerpen:
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3746020/
https://ncbi.nlm.nih.gov/pubmed/23827704
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.stem.2013.06.008
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