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Notching up MYC gives a LIC
King et al. (Cell, 2013) show that mutations in the ubiquitin ligase subcomponent FBXW7 increase MYC protein levels and expand the number of leukemia initiating cells (LIC) in Notch1-induced T-ALL. Genetic and pharmacological inhibition of Myc abolishes LIC activity with broader therapeutic implicat...
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| Main Authors: | , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2013
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3746020/ https://ncbi.nlm.nih.gov/pubmed/23827704 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.stem.2013.06.008 |
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