Genetic and chemical targeting of epithelial-restricted with serine box reduces epidermal growth factor receptor and potentiates the efficacy of afatinib

Epidermal growth factor receptor (EGFR) is elevated in over 90% of head and neck squamous cell carcinoma (HNSCC). However, a majority of HNSCC patients do not respond to anti-EGFR therapeutics. Insensitivity to EGFR inhibitors may be due to kinase-independent actions of EGFR and/or activation of Her...

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Detalhes bibliográficos
Main Authors: Zhang, Manchao, Taylor, Christopher E., Piao, Longzhu, Datta, Jharna, Bruno, Paul A., Bhave, Sanjay, Su, Tizhi, Lang, James C., Xie, Xiujie, Teknos, Theodoros N., Mapp, Anna K., Pan, Quintin
Formato: Artigo
Idioma:Inglês
Publicado em: 2013
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3746004/
https://ncbi.nlm.nih.gov/pubmed/23723125
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1535-7163.MCT-12-1110
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