Inhibition of the Growth Factor MDK/Midkine by a Novel Small Molecule Compound to Treat Non-Small Cell Lung Cancer

Midkine (MDK) is a heparin-binding growth factor that is highly expressed in many malignant tumors, including lung cancers. MDK activates the PI3K pathway and induces anti-apoptotic activity, in turn enhancing the survival of tumors. Therefore, the inhibition of MDK is considered a potential strateg...

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Bibliographic Details
Main Authors: Hao, Huifang, Maeda, Yutaka, Fukazawa, Takuya, Yamatsuji, Tomoki, Takaoka, Munenori, Bao, Xiao-Hong, Matsuoka, Junji, Okui, Tatsuo, Shimo, Tsuyoshi, Takigawa, Nagio, Tomono, Yasuko, Nakajima, Motowo, Fink-Baldauf, Iris M., Nelson, Sandra, Seibel, William, Papoian, Ruben, Whitsett, Jeffrey A., Naomoto, Yoshio
Format: Artigo
Language:Inglês
Published: Public Library of Science 2013
Subjects:
Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3745462/
https://ncbi.nlm.nih.gov/pubmed/23976985
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0071093
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