Nimotuzumab Enhances the Radiosensitivity of Cancer Cells In Vitro by Inhibiting Radiation-Induced DNA Damage Repair

BACKGROUND: Nimotuzumab is a humanized IgG1 monoclonal antibody specifically targeting EGFR. In this study, we aimed to investigate the molecular mechanisms of nimotuzumab in its effects of enhancing cancer cell radiosensitivity. PRINCIPAL FINDING: Lung cancer A549 cells and breast cancer MCF-7 cell...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Prif Awduron: Qu, Yuan-yuan, Hu, Song-liu, Xu, Xiang-ying, Wang, Rui-zhi, Yu, Hong-yang, Xu, Jian-yu, Chen, Lin, Dong, Guang-lu
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: Public Library of Science 2013
Pynciau:
Research Article
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC3745376/
https://ncbi.nlm.nih.gov/pubmed/23976954
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0070727
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