Allosteric Coupling in the Bacterial Adhesive Protein FimH

The protein FimH is expressed by the majority of commensal and uropathogenic strains of Escherichia coli on the tips of type 1 fimbriae and mediates adhesion via a catch bond to its ligand mannose. Crystal structures of FimH show an allosteric conformational change, but it remains unclear whether al...

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Bibliographic Details
Main Authors: Rodriguez, Victoria B., Kidd, Brian A., Interlandi, Gianluca, Tchesnokova, Veronika, Sokurenko, Evgeni V., Thomas, Wendy E.
Format: Artigo
Language:Inglês
Published: American Society for Biochemistry and Molecular Biology 2013
Subjects:
Microbiology
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3745355/
https://ncbi.nlm.nih.gov/pubmed/23821547
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M113.461376
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