Manipulating the mammalian genome by homologous recombination
Gene targeting in mammalian cells has proven invaluable in biotechnology, in studies of gene structure and function, and in understanding chromosome dynamics. It also offers a potential tool for gene-therapeutic applications. Two limitations constrain the current technology: the low rate of homologo...
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| Udgivet i: | Proc Natl Acad Sci U S A |
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| Principais autores: | , , , |
| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
National Academy of Sciences
2001
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC37450/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/11459982/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.111009698 |
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