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Manipulating the mammalian genome by homologous recombination

Gene targeting in mammalian cells has proven invaluable in biotechnology, in studies of gene structure and function, and in understanding chromosome dynamics. It also offers a potential tool for gene-therapeutic applications. Two limitations constrain the current technology: the low rate of homologo...

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Detalhes bibliográficos
Main Authors: Vasquez, Karen M., Marburger, Kathleen, Intody, Zsofia, Wilson, John H.
Formato: Artigo
Idioma:Inglês
Publicado em: The National Academy of Sciences 2001
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC37450/
https://ncbi.nlm.nih.gov/pubmed/11459982
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.111009698
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