Pyrazolo[1,5-a]-1,3,5-triazine as a purine bioisostere: access to potent CDK inhibitor (R)-roscovitine analogue

Pharmacological inhibitors of cyclin-dependent kinases (CDKs) have a wide therapeutic potential. Among the CDK inhibitors currently under clinical trials, the 2,6,9-trisubstituted purine (R)-roscovitine displays rather high selectivity, low toxicity, and promising antitumor activity. In an effort to...

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Detalhes bibliográficos
Main Authors: Popowycz, Florence, Fournet, Guy, Schneider, Cédric, Bettayeb, Karima, Ferandin, Yoan, Lamigeon, Cyrile, Tirado, Oscar M., Mateo-Lozano, Silvia, Notario, Vicente, Colas, Pierre, Bernard, Philippe, Meijer, Laurent, Joseph, Benoît
Formato: Artigo
Idioma:Inglês
Publicado em: 2009
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3744883/
https://ncbi.nlm.nih.gov/pubmed/19128055
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jm801340z
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