Impaired replication elongation in Tetrahymena mutants deficient in histone H3 Lys 27 monomethylation

Replication of nuclear DNA occurs in the context of chromatin and is influenced by histone modifications. In the ciliate Tetrahymena thermophila, we identified TXR1, encoding a histone methyltransferase. TXR1 deletion resulted in severe DNA replication stress, manifested by the accumulation of ssDNA...

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Библиографические подробности
Главные авторы: Gao, Shan, Xiong, Jie, Zhang, Chunchao, Berquist, Brian R., Yang, Rendong, Zhao, Meng, Molascon, Anthony J., Kwiatkowski, Shaina Y., Yuan, Dongxia, Qin, Zhaohui, Wen, Jianfan, Kapler, Geoffrey M., Andrews, Philip C., Miao, Wei, Liu, Yifan
Формат: Artigo
Язык:Inglês
Опубликовано: Cold Spring Harbor Laboratory Press 2013
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Research Paper
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC3744725/
https://ncbi.nlm.nih.gov/pubmed/23884606
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gad.218966.113
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