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Impaired replication elongation in Tetrahymena mutants deficient in histone H3 Lys 27 monomethylation

Replication of nuclear DNA occurs in the context of chromatin and is influenced by histone modifications. In the ciliate Tetrahymena thermophila, we identified TXR1, encoding a histone methyltransferase. TXR1 deletion resulted in severe DNA replication stress, manifested by the accumulation of ssDNA...

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Detalhes bibliográficos
Main Authors: Gao, Shan, Xiong, Jie, Zhang, Chunchao, Berquist, Brian R., Yang, Rendong, Zhao, Meng, Molascon, Anthony J., Kwiatkowski, Shaina Y., Yuan, Dongxia, Qin, Zhaohui, Wen, Jianfan, Kapler, Geoffrey M., Andrews, Philip C., Miao, Wei, Liu, Yifan
Formato: Artigo
Idioma:Inglês
Publicado em: Cold Spring Harbor Laboratory Press 2013
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3744725/
https://ncbi.nlm.nih.gov/pubmed/23884606
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gad.218966.113
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