Analysis of Trafficking, Stability and Function of Human Connexin 26 Gap Junction Channels with Deafness-Causing Mutations in the Fourth Transmembrane Helix

Human Connexin26 gene mutations cause hearing loss. These hereditary mutations are the leading cause of childhood deafness worldwide. Mutations in gap junction proteins (connexins) can impair intercellular communication by eliminating protein synthesis, mis-trafficking, or inducing channels that fai...

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Bibliografische gegevens
Hoofdauteurs: Ambrosi, Cinzia, Walker, Amy E., DePriest, Adam D., Cone, Angela C., Lu, Connie, Badger, John, Skerrett, I. Martha, Sosinsky, Gina E.
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: Public Library of Science 2013
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Research Article
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3744544/
https://ncbi.nlm.nih.gov/pubmed/23967136
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0070916
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