Phosphoantigen/IL2 Expansion and Differentiation of Vγ2Vδ2 T Cells Increase Resistance to Tuberculosis in Nonhuman Primates

Dominant Vγ2Vδ2 T-cell subset exist only in primates, and recognize phosphoantigen from selected pathogens including M. tuberculosis(Mtb). In vivo function of Vγ2Vδ2 T cells in tuberculosis remains unknown. We conducted mechanistic studies to determine whether earlier expansion/differentiation of Vγ...

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Detalhes bibliográficos
Main Authors: Chen, Crystal Y., Yao, Shuyu, Huang, Dan, Wei, Huiyong, Sicard, Helene, Zeng, Gucheng, Jomaa, Hassan, Larsen, Michelle H., Jacobs, William R., Wang, Richard, Letvin, Norman, Shen, Yun, Qiu, Liyou, Shen, Ling, Chen, Zheng W.
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2013
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3744401/
https://ncbi.nlm.nih.gov/pubmed/23966854
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.ppat.1003501
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