Histone deacetylase inhibitor (HDACI) PCI-24781 enhances chemotherapy induced apoptosis in multidrug resistant sarcoma cell lines

The anti-tumor activity of histone deacetylase inhibitors (HDACI) on multi-drug resistant sarcoma cell lines has never been previously described. Four multidrug resistant sarcoma cell lines treated with HDACI PCI-24781 resulted in dose-dependent accumulation of acetylated histones, p21 and PARP clea...

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Autori principali: Yang, Cao, Choy, Edwin, Hornicek, Francis J., Wood, Kirkham B, Schwab, Joseph H, Liu, Xianzhe, Mankin, Henry, Duan, Zhenfeng
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2011
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3744220/
https://ncbi.nlm.nih.gov/pubmed/21508354
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